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ea0029p583 | Diabetes | ICEECE2012

Identification of dipeptidyl peptidase-4 inhibitors among boioactive peptides derived from whey proteins

Tulipano G , Faggi L , Caroli A , Cocchi D

Preclinical and clinical studies suggest that whey protein intake can ameliorate postprandial glucose control and potentiate insulin release in both type-2 diabetic patients and healthy subjects.Most likely, the insulinotropic effect of whey occurs by multiple pathways, including the potentiation of incretin activity through inhibition of DPP-4 in the proximal bowel, with the outcome of increasing intact incretin levels.During last...

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ea0029p1352 | Pituitary Basic | ICEECE2012

Effects of the combined treatment with AMPK activator and somatostatin-14 on hormone secretion and cell proliferation in cultured GH-secreting pituitary tumor cells

Tulipano G. , Faggi L. , Losa M. , Mortini P. , Spinello M. , Cocchi D. , Giustina A.

AMP-activated protein kinase (AMPK) activation decreased GH release and intracellular GH storage in rat pituitary cell cultures and reduced cell proliferation in rat pituitary adenomatous cells (GH3) cultures.We investigated the effects of the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) as compared to somatostatin-14 on cell viability (MTT assay after 48-h) and GH secretion (over 24 h) in 16 human GH-secreting pituitary adenomas ...

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Endocrine Abstracts

Identification of dipeptidyl peptidase-4 inhibitors among boioactive peptides derived from whey proteins

Effects of the combined treatment with AMPK activator and somatostatin-14 on hormone secretion and cell proliferation in cultured GH-secreting pituitary tumor cells

BiosciAbstracts